At the Atomic-Scale Materials Science & Electron Microscopy Laboratory, we focus on understanding how structure governs the properties and function of materials at the atomic scale. Leveraging advanced transmission electron microscopy, spectroscopy, in situ characterization, and machine-learning-based data analysis, we reveal how composition, interfaces, defects, and local atomic structure influence material behavior. These insights guide the design of materials with tailored optical, electronic, magnetic, mechanical, quantum, and thermal properties for applications in quantum technologies, electronics, optoelectronics, catalysis, and energy.